LUMINATE

LUMINATE is pioneering a personalized, one-stage regenerative therapy for large osteochondral knee lesions to prevent post-traumatic  osteoarthritis (PTOA) and reduce the need for invasive joint replacement. At the core of the project is EndoFLight, a next-generation in situ bioprinting platform that integrates micro-extrusion, jetting, and filamented light (FLight) technologies to deliver patient-derived cells and biomaterials directly at the site of injury. This minimally invasive approach enables rapid and precise reconstruction of native osteochondral architecture, supporting long-term functional restoration of the joint.

The project is structured into 10 work packages and distributed among 15 partners, including 11 leading academic institutions and 4 innovative companies, from across the EU+ region. This highly interdisciplinary consortium unites expertise from engineering, biology, materials science, and clinical practice, ensuring that innovation is translated effectively from bench to bedside. LUMINATE will validate EndoFLight in clinically relevant models while advancing regulatory, translational, and commercialization pathways to maximize patient benefit and socioeconomic impact.